Since 2009, Operation Smile has conducted medical programs in the cities of La Romana, Santo Domingo, and La Vega. In 2013, Operation Smile partnered with professors and students at Universidad Iberoamericana in Santo Domingo to launch the country’s first dental program. Additionally, in 2014, Operation Smile hosted the first annual Central America and the Caribbean Education Conference for volunteers in the specialties of anesthesiology, pediatrics, dentistry, and plastic surgery in the Dominican Republic.
Operation Smile's global volunteer network includes dozens of medical professionals as well as hundreds of non-medical volunteers from the Dominican Republic working to treat children in the Dominican Republic as well as the rest of Latin American and the Caribbean. Over the past six years, Operation Smile has provided free reconstructive surgery to more than 1,100 patients in the Dominican Republic.